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SAGES STORY FOLLOW UP
(Back
to part 1)
I received the faxed copy
of Sage's autopsy report on 4/17/00. They
tested for the following:
1) Ehrlichia platys IFA (LSU) results:
Negative,
comments: <1:40
2) Rocky Mt. Spotted Fever (UofTN)
comment: <1:40 comment: Antibody titers
of less than 1:40 are considered
negative; titers of 1:40 or greater are considered positive.
3) Anticoag Screen results: not detected with the following toxins
included in the Anticoagulant Screen:
Fumarin
Racumin
Warfarin
Coumachlor
Difenacoum
Brodifacoum
Diphacinone
Pindone
Valone
Chlorophacinone
Bromadiolone
4-OH Warfarin
6-OH Warfarin
7-OH Warfarin
8-OH Warfarin
Difethialone
This next section is directly
from the report.
Comments: The most likely
cause of this dog's death is cardiovascular collapse resulting from hemorrhage
noted clinically and histologically in conjunction with the severe changes
decribed in the heart. Of particular interest is the absence of magakaryocytes
(platelet precursor cells) from all tissues examined, especially in light
of the clinical history of thrombocytopenia, hemorrhage, and the presence
of a regenerative anemia.
Given this finding, a
defect in platelet production (progenitor cell, stem cell, CFU_Meg, etc.)
must be considered a potential cause of the thromocytopenia. The
immune-mediated destruction of megakaryocytic precursor cells has been
described in dogs. It should be noted that the most critical site
of platelet production, the bone marrow, was not provided for histopathologic
examination: therefore, further interpretation is severely hindered.
MICROSCOPIC DIAGNOSES:
1. Moderate, Acute,
Pulmonary Edema
2. Pneumoconiosis
3. Extramedullary
Hematopoiesis, Splenic and Hepatic
4. Moderate, Acute,
Multifocal Renal Interstitial Hemorrhage
5. Marked to Severe,
Acute, Multifocalo to Coalescing Myocardial Interstitial Hemorrhage with
Edema
6. Mild, Acute,
Diffuse Vacuolar Change, Hepatocellular
7. Moderate, Acute
Vascular Congestion, Meningeal with Mild Perivascular Hemorrhage.
I believe that Sage had
a borderline Autoimmune Disease. She would bruise easily but had
no problems with her blood clotting in the past; ex: she was spayed.
An example I was given by one of her Vets, was this: It was
as if she was standing
at the edge of a cliff on sure footing until something (Revolution,
in this case) came along and pushed her over the edge.
I want to thank everyone
for the responses I received from my story of Sage. She was a loyal
and loving dog. We miss her everyday! Please if you have a
dog with a bruising history like Sage, PLEASE Think carefully before using
this product.
Sincerely,
Terri
Eddy
Rincon, GA.
Another tidbit for you
to digest here: Pfizer is ALSO the manufacturer of RIMADYL,
which is also the subject of some close scrutiny for its involvement in
illness and deaths in some canine patients who were taking it.
Here is the URL for Revolutions
Website: http://www.revolutionpet.com/revconsumer/
Revolution
Prescribing Info
Info
on Safety Studies Performed
FDA
Freedom Of Information Re: Revolution
National
Animal Poison Control Center
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